Google Patents.Ĭruccu G, Aziz TZ, Garcia-Larrea L, Hansson P, Jensen TS, Lefaucheur JP, Simpson BA, Taylor RS (2007) EFNS guidelines on neurostimulation therapy for neuropathic pain. Maurer D (1974) Transcutaneous stimulator and stimulation method. doi: 10.1136/bmj.b3002Īllegrante JP (1996) The role of adjunctive therapy in the management of chronic nonmalignant pain. doi: 10.1016/j.tins.2003.09.017įreynhagen R, Bennett MI (2009) Diagnosis and management of neuropathic pain. Ji RR, Kohno T, Moore KA, Woolf CJ (2003) Central sensitization and LTP: do pain and memory share similar mechanisms? Trends Neurosci 26:696–705. Zimmermann M (2001) Pathobiology of neuropathic pain. Woolf CJ, Doubell TP (1994) The pathophysiology of chronic pain-increased sensitivity to low threshold A beta-fibre inputs. Merskey H, Harold E (1986) Classification of chronic pain: descriptions of chronic pain syndromes and definitions of pain terms. Merskey H, Bogduk N (1994) Classification of chronic pain, 2nd edn. Stewart WF, Ricci JA, Chee E, Morganstein D, Lipton R (2003) Lost productive time and cost due to common pain conditions in the US workforce. J Pain Pall Care Phmaracotherapy 26:197–198 Simon L (2012) Relieving pain in America: A blueprint for transforming prevention, care, education, and research. Larger, randomized studies are required to further evaluate the efficacy of this approach. The positive findings from preliminary studies with Scrambler Therapy support that this device provides benefit for patients with refractory pain syndromes. To date, 20 reports, of varying scientific quality, have been published regarding this device all but one small study, published only as an abstract, provided results that appear positive. All case studies and clinical trials were evaluated and reported in a descriptive manner. The PubMed/Medline, SCOPUS, EMBASE, and Google Scholar databases were searched for all articles published on Scrambler Therapy prior to November 2015.

This review was conducted to further evaluate what is known regarding the mechanisms and mechanics of Scrambler Therapy and to investigate the preliminary data pertaining to the efficacy of this treatment modality. Scrambler Therapy is a novel, non-invasive pain modifying technique that utilizes trans-cutaneous electrical stimulation of pain fibers with the intent of re-organizing maladaptive signaling pathways.

Although many pharmacologic and behavioral strategies exist for the management of this condition, treatment is often unsatisfactory. Chronic pain is a widespread and debilitating condition, encountered by physicians in a variety of practice settings.

Scrambler therapy